Atherosclerosis causes

Atherosclerosis causes

Atherosclerosis causes not yet fully understand, but with the following known factor (risk factor) is closely related to:

First, hypertension clinical and autopsy data show that patients with hypertension atherosclerosis incidence rate was higher. This may be due to hypertension, artery wall under the special high-pressure, endometrial layer and endothelial cells of the injury, low-density lipoprotein easy to enter the artery wall, and stimulate smooth muscle cell proliferation and trigger atherosclerosis.

Second, hyperlipidemia clinical data show that atherosclerosis is common in hypercholesterolemia. Laboratory animals given high-cholesterol diet can cause atherosclerosis. In recent years, the study found that low-density lipoprotein and the extremely high density lipoprotein and the reduction of high-density lipoprotein and atherosclerosis-related. The increase in blood triglyceride and atherosclerosis in a certain relationship. Recent research found that a lipoprotein [Lp (a)] and atherosclerosis is closely related to the occurrence.

Third, smoking smokers hemoglobin concentration of oxygen in the blood up to 10-20 percent, within the artery wall inadequate oxygenation, increased endometrial lower fatty acid synthesis, to reduce the release of PGI2, platelet adhesion easily gathered in the artery wall. In addition, smoking will also enable high-density lipoprotein in the blood of the original volume of lower serum cholesterol levels increased, so susceptible to atherosclerosis. In addition, smoking, nicotine contained in smoke can act on the heart and coronary artery spasm and cause myocardial damage.

4, diabetes associated with diabetes are more hypertriglyceridemia or hypercholesterolemia, again accompanied by hypertension, atherosclerosis, the incidence rate was higher. Diabetes also often the first factor Ⅷ increased blood platelet activity and enhanced. Factor Ⅷ from within the artery wall cells, the factor that increased the endometrial lesions, platelet activity easier to gather in the artery wall, accelerating atherosclerosis and thrombosis arising from the lumen of the artery occlusion. In recent years studies have suggested that insulin resistance and atherosclerosis is closely related to the occurrence, Ⅱ type 2 diabetes patients often have insulin resistance and hyperinsulinemia associated with coronary heart disease.

5, obesity is also atherosclerosis risk factors. Obesity can lead to plasma cholesterol and triglyceride levels increased, obesity is often accompanied or diabetes, hypertension, the study concluded that obesity in recent years often have insulin resistance, thus atherosclerosis significantly higher incidence rate.