Awareness of influenza virus

Influenza viruses are mucus Virus Unit, points A, B, C-3 was spherical or filaments, the diameter of 80 ~ 120 nm. 3 virus is similar to the biochemical and biological characteristics. Virus from the three-tier structure, lining for the virus nucleocapsid, with nucleoprotein (NP), P protein and RNA. NP is soluble antigen (S antigen), a type-specific antigen and stability. P protein (P1, P2, P3) may be required for RNA replication and the transcription polymerase. The middle for the virus capsule, and a layer of a lipid membrane protein (MP) constitute, MP antigen of stability, also of type-specific. For two different outer glycoprotein composed of radial processes, hemagglutinin (hemagglutinin, H) and neuraminidase (neuraminidase, N). H lectin can cause red blood cells, the virus is sensitive to adsorption on the surface of the tool, N, mucus can be hydrolyzed protein, hydrolyzed cell surface receptor-specific glycoprotein end of the N-acetyl neuraminidase, the virus is copied from the cell after the completion of Surface tool. H and N are variations of, the only strain-specific antigen, the antibody has a protective effect.
According to NP antigen, influenza virus will be divided into A, B, C-3. By H and N antigens different from the same virus subtype and a number of points. Influenza virus antigen variation is that H and N antigens structural changes, mainly H. Subtypes within the frequent occurrence in the small variation (quantity), referred to as antigen drift (antiganic drift). A variation of influenza virus antigen faster, 2 to 3 years may occur, the influenza B virus antigen variation is very slow. The large variation in the subtype antigen (qualitative) said that changes in antigen (antiganic shift), for its H and (or) N have undergone major changes in the resulting election of a new subtype that can cause worldwide pandemic . Variation of the strain of the virus known as variant. Influenza A virus occurred about every 10 years a large variation. Since 1933 the A virus antigen has undergone four changes: 1933 to 1946 for the H0N1 (the original A, A0), 1946 ~ 1957 as the H1N1 (-A, A1), 1957 ~ 1968 as the H2N2 ( Subtype A, A2) 1968 after the H3N2 (Hong Kong-based, A3). General evident between old and new subtype of the turn of the new subtype emerged and pop to a region, on the subtype of the old can no longer isolated. In addition, each subtype have taken place in some varieties. Influenza B treated equally between large and small variation variation, but not divided into subtypes change. Hepatitis C virus antigen variation have been found.
Common virus from chicken embryo culture. Common human embryonic cells cultured monkey kidney and organizations. Influenza virus does not heat and acid and ether, formaldehyde, ethanol and so sensitive to ultraviolet light.